Dosage Form:AML: 50 mg orally twice daily with food. ASM, SM-AHN, and MCL: 100 mg orally twice daily with food.
Side Effect:AML: The most common adverse reactions (≥ 20%) were febrile Initial U.S. Approval: 2017 neutropenia, nausea, mucositis, vomiting, headache, petechiae, musculoskeletal pain, epistaxis, device-related infection, hyperglycemia, and upper respiratory tract infection. • ASM, SM-AHN, or MCL: The most common adverse reactions (≥ 20%) with: were nausea, vomiting, diarrhea, edema, musculoskeletal pain, abdominal • Newly diagnosed acute myeloid leukemia (AML) that is FLT3 mutation- pain, fatigue, upper respiratory tract infection, constipation, pyrexia, positive as detected by an FDA-approved test, in combination with headache, and dyspnea